HSV-2 IgM and IgG Test Kits
HSV-2 IgG test and HSV-2 IgM test kits are used in the diagnosis of the genital herpes HSV-2 infection.
Intended Use
Herpes Simplex Virus type 2 (HSV-2) test kits are immunoassay test kits used to respectively detect the IgM and IgG antibody isotypes specific to HSV-2 virus in human serum or plasma samples.
Application of HSV-2 Test Kits
The detection of HSV-2 IgM antibody enables effective diagnosis of acute or recent infection of Herpes Simplex Virus 2. The test is particularly useful for the follow-up of pregnant women, who were not previously exposed to HSV-2 and consequently are not protected against the virus.
In addition, determination of specific IgM antibody in the newborn is useful for the diagnosis of congenital HSV-2 infection. If a patient has antibodies to HSV-2, it is indicative of infection with the virus regardless of symptomology. Determination of a patient's HSV-2 serological status using a isotype (IgG or IgM) specific antibody test enables the physician to make appropriate interventions for treatments and professional guidance.
Spread of HSV-1
HSV-2 is the primary cause of initial and recurrent genital herpes and neonatal HSV infection. Reactivation of latent HSV infection is a frequent complication of immunosuppression due to cancer, transplantation and AIDS.
Genital herpes can be more difficult to diagnose than oral herpes HSV-1, because most HSV-2-infected persons have no classical symptoms, and several other infection conditions resemble genital herpes. Laboratory methods are used in the diagnosis of HSV-2: culture of the virus, direct fluorescent antibody (DFA) studies, skin biopsy, and polymerase chain reaction (PCR). The high costs and long waiting time discourage their regular use. The newly developed HSV-2 dot assay and rapid test kits are more than 98% specific at discriminating HSV-1 from HSV-2 infection.
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