dsDNA IgG Antibody Dot Filtration Assay Kit

dsDNA IgG DOT rapid Test

dsDNA IgG Dot Assay kit and dsDNA IgG ELISA kit are intended for use in the detection of IgG antibody specific to double stranded DNA (ds-DNA) in human serum, as an important clinical indicator in the diagnosis of the systemic Lupus Erythematosus (SLE) as well as Rheumatoid Arthritis.

In the dsDNA rapid test kit, purified ds-DNA antigen is coated on the surface of membrane. During testing, the ds-DNA IgG antibody, if present, will be captured by the dsDNA antigen and be fixed on the membrane. Then after washing away the serum specimen to clear the unbound proteins, the reagent containing antibody to human IgG (anti-IgG) antibody conjugated with colloidal gold particles is added, the bound ds-DNA antibody will capture the anti-IgG-colloidal gold particles. The accumulation of the colloidal gold particle on the testing spot region will show a colored spot, indicating a positive result of dsDNA IgG antibody.

dsDNA Antibody and Rheumatoid Arthritis

The systemic lupus erythematosus (SLE) is a systemic autoimmune disease that can affect any part of the body, including the heart, joints, skin, lungs, blood vessels, liver, kidneys, and nervous system. Under hypersensitivity reaction, the immune system attacks the body's cells and tissue, resulting in inflammation and tissue damage. The course of the disease is unpredictable. SLE is treatable through addressing its symptoms, mainly with cyclophosphamide, corticosteroids and immune-suppressants; there is currently no cure. SLE can be fatal, although with recent medical advances, fatalities are becoming increasingly rare.

Antibodies reacting with native double-stranded DNA are regarded as being specific to systemic lupus erythematosus (SLE) and can be detected in approximately 50-80% of the SLE patients. Antibodies against dsDNA are found during active phases of SLE, their serum concentration tend to positively correlate with the severity of the disease. Thus, detection of these autoantibodies is important for the diagnosis and clinical monitoring of the disease and consequently has been established as 1 of the 11 American College of Rheumatology (ACR) criteria for the diagnosis of SLE.

ds-DNA IgG Antibody Immunoassay Kits

No.Cat. No.Description
(Click For Details)
SpecimenPCS/BoxQuan. per CTN Quantity Interested* Add to
1 dsDNA R422 Double Stranded DNA IgG DOT Assay serum 25 Bulk: 1200 PCS
Boxed: 36 Boxes
2 dsDNA R424 Double Stranded DNA IgG ELISA Kit serum 48/96T Boxed: 40 Kits boxes
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  2. dsDNA IgG antibody is one of the most commonly tested antibody isotypes in the diagnosis of Rheumatoid Arthritis.
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